{"id":623,"date":"2011-05-03T13:40:03","date_gmt":"2011-05-03T12:40:03","guid":{"rendered":"https:\/\/ozonetherapyglobaljournal.es\/?p=623\/"},"modified":"2017-07-10T02:17:05","modified_gmt":"2017-07-10T01:17:05","slug":"effect-of-ozone-therapy-on-redox-status-in-experimentally-induced-arthritis","status":"publish","type":"post","link":"https:\/\/ozonetherapyglobaljournal.es\/en\/effect-of-ozone-therapy-on-redox-status-in-experimentally-induced-arthritis\/","title":{"rendered":"Effect of ozone therapy on redox status in experimentally induced arthritis"},"content":{"rendered":"

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Original Paper<\/strong><\/h2>\n
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Authors<\/h3>\n

M.Nabil. Mawsouf, Maha.M. El-Sawalhi, Hebatalla A. Darwish, Amira A. Shaheen, Gregorio Mart\u00ednez-S\u00e1nchez, Lamberto Re<\/em><\/p>\n

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Keywords<\/h3>\n

Ozone, Oxidative preconditioning, Oxidative postconditioning, experimental arthritis<\/p>\n

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Abstract<\/strong><\/h3>\n
Controlled ozone administration has been shown to promote an adaptation to oxidative stress by increasing endogenous antioxidant systems. In the present study, the effects of O2\/O3 administration either prophylactically or therapeutically on the alterations of oxidant status in adjuvant-induced arthritis in rats have been studied. Seven groups of rats were used: 1) normal control group; 2) control arthritic group (21 days); 3) prophylactic ozone group: arthritic rats received fifteen intra-rectal applications of O2\/O3 at 0.5, 0.7 and 1 mg\/kg b.w. in a 5-6 mL volume starting one day before adjuvant inoculation and continued as five applications\/week over 21 days; 4) oxygen group: received oxygen (vehicle of ozone) in a similar schedule to group 3; 5) control arthritic group (24 days); 6) therapeutic-ozone group: arthritic rats received 10 intra-rectal applications of O2\/O3 at 0.5, 0.7 and 1 mg\/kg b. w. in a 5-6 mL volume daily for 10 days starting fourteen days after adjuvant inoculation; 7) oxygen-treated group: received oxygen in a similar schedule of group 6. The effect of O2\/O3 administration was assessed by measuring: blood glutathione (GSH), erythrocyte glutathione peroxidase and catalase activities, serum levels of protein thiols (PrSH), malondialdehyde (MDA) and nitrite\/nitrate (NO2\/NO3), as well as serum ceruloplasmin activity (CP). The present study showed that adjuvant-induced arthritis in rats caused a significant (p<0.05) reduction in blood GSH, serum PrSH levels and erythrocyte antioxidant enzyme activities accompanied by a significant (p<0.05) increase in serum levels of MDA, NO2\/NO3 and CP activity. Ozone administration either prophylactically or therapeutically normalize blood GSH, serum PrSH and MDA levels and restored erythrocyte antioxidant enzyme activities. However ozone did not significantly (p>0.05) modify serum NO2\/NO3 level in induced rat but significant (p<0.05) increase CP activity. So it could be concluded that O2\/O3 oxidative preconditioning \/ postconditioning effectively modulate the antioxidant\/oxidant balance associated with adjuvant arthritis model in rats.<\/div>\n
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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

[et_pb_section bb_built=”1″ admin_label=”section”][et_pb_row admin_label=”row”][et_pb_column type=”4_4″][et_pb_text admin_label=”Texto” background_layout=”light” text_orientation=”justified” use_border_color=”off” border_color=”#000000″ border_style=”solid” saved_tabs=”all”] Original Paper Authors M.Nabil. Mawsouf, Maha.M. El-Sawalhi, Hebatalla A. Darwish, Amira A. Shaheen, Gregorio Mart\u00ednez-S\u00e1nchez, Lamberto Re   Keywords Ozone, Oxidative preconditioning, Oxidative postconditioning, experimental arthritis   Abstract Controlled ozone administration has been shown to promote an adaptation to oxidative stress by increasing […]<\/p>\n","protected":false},"author":1,"featured_media":526,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[236],"tags":[457,303,304,306],"_links":{"self":[{"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/posts\/623"}],"collection":[{"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/comments?post=623"}],"version-history":[{"count":1,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/posts\/623\/revisions"}],"predecessor-version":[{"id":624,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/posts\/623\/revisions\/624"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/media\/526"}],"wp:attachment":[{"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/media?parent=623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/categories?post=623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ozonetherapyglobaljournal.es\/en\/wp-json\/wp\/v2\/tags?post=623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}